Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride

We investigated, for the first time, the potential for a hydrogel-forming microneedle (MN) patch to deliver the high-dose drug metformin HCl transdermally in a sustained manner. This may minimize some gastrointestinal side effects and small intestine absorption variations associated with oral delive...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Migdadi, Eman M., Courtenay, Aaron J., Tekko, Ismaiel A., McCrudden, Maelíosa T.C., Kearney, Mary-Carmel, McAlister, Emma, McCarthy, Helen O., Donnelly, Ryan F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Publishers 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141810/
https://ncbi.nlm.nih.gov/pubmed/29990526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.07.009
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