Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells

Mutation in minor spliceosome components is linked to the developmental disorder microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1). Here, we inactivated the minor spliceosome in the developing mouse cortex (pallium) by ablating Rnu11, which encodes the crucial minor spliceosome small...

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Vydáno v:Development
Hlavní autoři: Baumgartner, Marybeth, Olthof, Anouk M., Aquino, Gabriela S., Hyatt, Katery C., Lemoine, Christopher, Drake, Kyle, Sturrock, Nikita, Nguyen, Nhut, al Seesi, Sahar, Kanadia, Rahul N.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2018
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141777/
https://ncbi.nlm.nih.gov/pubmed/30093551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.166322
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