Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration

We previously identified Fam65b as an atypical inhibitor of the small G protein RhoA. Using a conditional model of a Fam65b-deficient mouse, we first show that Fam65b restricts spontaneous RhoA activation in resting T lymphocytes and regulates intranodal T cell migration in vivo. We next aimed at un...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Megrelis, Laura, El Ghoul, Elyas, Moalli, Federica, Versapuech, Margaux, Cassim, Shamir, Ruef, Nora, Stein, Jens V., Mangeney, Marianne, Delon, Jérôme
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141708/
https://ncbi.nlm.nih.gov/pubmed/30254631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02001
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