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Caffeine inhibition of GLUT1 is dependent on the activation state of the transporter
Caffeine has been shown to be a robust uncompetitive inhibitor of glucose uptake in erythrocytes. It preferentially binds to the nucleotide-binding site on GLUT1 in its tetrameric form and mimics the inhibitory action of ATP. Here we demonstrate that caffeine is also a dose-dependent, uncompetitive...
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| Publié dans: | Biochimie |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6141003/ https://ncbi.nlm.nih.gov/pubmed/28322926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2017.03.011 |
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