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A Luminal Loop of Wilson Disease Protein Binds Copper and Is Required for Protein Activity
The copper-transporting ATPase ATP7B is essential for loading of copper ions to copper-dependent enzymes in the secretory pathway; its inactivation results in Wilson disease. In contrast to copper-ion uptake by the cytoplasmic domains, ATP7B-mediated copper-ion release in the Golgi has not been expl...
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| Veröffentlicht in: | Biophys J |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6139820/ https://ncbi.nlm.nih.gov/pubmed/30173886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.07.040 |
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