Apelin and APJ orchestrate complex tissue-specific control of cardiomyocyte hypertrophy and contractility in the hypertrophy-heart failure transition

The G protein-coupled receptor APJ is a promising therapeutic target for heart failure. Constitutive deletion of APJ in the mouse is protective against the hypertrophy-heart failure transition via elimination of ligand-independent, β-arrestin-dependent stretch transduction. However, the cellular ori...

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Udgivet i:Am J Physiol Heart Circ Physiol
Main Authors: Parikh, Victoria N., Liu, Jing, Shang, Ching, Woods, Christopher, Chang, Alex C., Zhao, Mingming, Charo, David N., Grunwald, Zachary, Huang, Yong, Seo, Kinya, Tsao, Philip S., Bernstein, Daniel, Ruiz-Lozano, Pilar, Quertermous, Thomas, Ashley, Euan A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139625/
https://ncbi.nlm.nih.gov/pubmed/29775410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00693.2017
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