Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofuscin and drusen on the retinal pigment epithelium (RPE). Both oxidative stress and autophagic dysfunction accelerate the deposition of lipofuscin at the RPE. One of the key regulators in the response a...

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Detalhes bibliográficos
Publicado no:Redox Biol
Principais autores: Saito, Yuichi, Kuse, Yoshiki, Inoue, Yuki, Nakamura, Shinsuke, Hara, Hideaki, Shimazawa, Masamitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138993/
https://ncbi.nlm.nih.gov/pubmed/30216854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.09.004
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