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Testing the potency of anti-TNF-α and anti-IL-1β drugs using spheroid cultures of human osteoarthritic chondrocytes and donor-matched chondrogenically differentiated mesenchymal stem cells

Inflammation plays a major role in progression of rheumatoid arthritis (RA), a disease treated with antagonists of tumor necrosis factor-alpha (TNF-α) and interleukin 1β (IL-1β). New in vitro testing systems are needed to evaluate efficacies of new anti-inflammatory biological drugs, ideally in a pa...

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Dades bibliogràfiques
Publicat a:Biotechnol Prog
Autors principals: Žigon-Branc, Sara, Barlič, Ariana, Knežević, Miomir, Jeras, Matjaž, Vunjak-Novakovic, Gordana
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138577/
https://ncbi.nlm.nih.gov/pubmed/29536646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.2629
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