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Tissue Specificity of L-Pyruvate Kinase Transgenes Results From the Combinatorial Effect of Proximal Promoter and Distal Activator Regions

The L-type pyruvate kinase (L-PK) gene is regulated by diet and hormones and expressed at high levels in the hepatocytes, enterocytes, and proximal tubular cells of the kidney and at low levels in the endocrine pancreatic cells. Two regulatory regions have been shown to be important in transgenic mi...

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Detalhes bibliográficos
Publicado no:Gene Expr
Main Authors: Miquerol, Lucile, Cluzeaud, Françoise, Porteu, Arlette, Alexandre, Yvonne, Vandewalle, Alain, Kahn, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: Cognizant Communication Corporation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138020/
https://ncbi.nlm.nih.gov/pubmed/8836739
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