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Tissue Specificity of L-Pyruvate Kinase Transgenes Results From the Combinatorial Effect of Proximal Promoter and Distal Activator Regions

The L-type pyruvate kinase (L-PK) gene is regulated by diet and hormones and expressed at high levels in the hepatocytes, enterocytes, and proximal tubular cells of the kidney and at low levels in the endocrine pancreatic cells. Two regulatory regions have been shown to be important in transgenic mi...

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Vydáno v:Gene Expr
Hlavní autoři: Miquerol, Lucile, Cluzeaud, Françoise, Porteu, Arlette, Alexandre, Yvonne, Vandewalle, Alain, Kahn, Axel
Médium: Artigo
Jazyk:Inglês
Vydáno: Cognizant Communication Corporation 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6138020/
https://ncbi.nlm.nih.gov/pubmed/8836739
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