Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties

PURPOSE: Development of new semisynthetic glycopeptides with improved antibacterial efficacy and reduced pseudoallergic reactions. METHODS: Semisynthetic glycopeptides 3–6 were synthesized from vancomycin (1) or eremomycin (2) by the condensation with pyrrolidine or piperidine. The minimum inhibitor...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Olsufyeva, Evgenia N, Shchekotikhin, Andrey E, Bychkova, Elena N, Pereverzeva, Eleonora R, Treshalin, Ivan D, Mirchink, Elena P, Isakova, Elena B, Chernobrovkin, Mikhail G, Kozlov, Roman S, Dekhnich, Andrey V, Preobrazhenskaya, Maria N
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137948/
https://ncbi.nlm.nih.gov/pubmed/30237697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S173923
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