mTORC1 Negatively Regulates the Replication of Classical Swine Fever Virus Through Autophagy and IRES-Dependent Translation

Classical swine fever virus (CSFV) can utilize diverse host signaling pathways for its replication; however, the cross talk between mammalian target of rapamycin (mTOR) and CSFV remains unknown. Here, we describe the potential role of mTOR complex 1 (mTORC1) in promoting CSFV replication via virus-i...

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Gepubliceerd in:iScience
Hoofdauteurs: Luo, Qinghua, Zhang, Li, Wei, Feng, Fang, Qiang, Bao, Fei, Mi, Shijiang, Li, Nan, Wang, Chengming, Liu, Yan, Tu, Changchun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137324/
https://ncbi.nlm.nih.gov/pubmed/30428332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.04.010
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