Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer

Radiation therapy induces immunogenic cell death, which can theoretically stimulate T cell priming and induction of tumor-specific memory T cell responses, serving as an in situ vaccine. In practice, this abscopal effect is rarely observed. We use two mouse models of pancreatic cancer to show that a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Yasmin-Karim, Sayeda, Bruck, Patrick T., Moreau, Michele, Kunjachan, Sijumon, Chen, Gui Zhen, Kumar, Rajiv, Grabow, Stephanie, Dougan, Stephanie K., Ngwa, Wilfred
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137176/
https://ncbi.nlm.nih.gov/pubmed/30245691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02030
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