Chemokine receptor engineering of T cells with CXCR2 improves homing towards subcutaneous human melanomas in xenograft mouse model

Adoptive cell therapy (ACT) using in vitro expanded tumor infiltrating T lymphocytes (TILs) from biopsy material represents a highly promising treatment of disseminated cancer. A crucial prerequisite for successful ACT is sufficient recruitment of transferred lymphocytes to the tumor site; however,...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Idorn, Manja, Skadborg, Signe Koggersbøl, Kellermann, Lauge, Halldórsdóttir, Hólmfrídur Rósa, Holmen Olofsson, Gitte, Met, Özcan, thor Straten, Per
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136860/
https://ncbi.nlm.nih.gov/pubmed/30221044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1450715
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