In vivo conversion of astrocytes into oligodendrocyte lineage cells with transcription factor Sox10; Promise for myelin repair in multiple sclerosis

Recent studies demonstrate that astroglial cells can be directly converted into functional neurons or oligodendrocytes. Here, we report that a single transcription factor Sox10 could reprogram astrocytes into oligodendrocyte-like cells, in vivo. For transdifferentiation, Sox10-GFP expressing viral p...

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Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Mokhtarzadeh Khanghahi, Akram, Satarian, Leila, Deng, Wenbin, Baharvand, Hossein, Javan, Mohammad
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136770/
https://ncbi.nlm.nih.gov/pubmed/30212518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203785
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