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Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells
Doxorubicin is one of the most effective chemotherapy drugs used against solid tumors in the treatment of several cancer types. Two different mechanisms, (i) intercalation of doxorubicin into DNA and inhibition of topoisomerase II leading to changes in chromatin structure, (ii) generation of free ra...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6135803/ https://ncbi.nlm.nih.gov/pubmed/30209405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31939-9 |
| Oznake: |
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