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Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells
Doxorubicin is one of the most effective chemotherapy drugs used against solid tumors in the treatment of several cancer types. Two different mechanisms, (i) intercalation of doxorubicin into DNA and inhibition of topoisomerase II leading to changes in chromatin structure, (ii) generation of free ra...
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| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6135803/ https://ncbi.nlm.nih.gov/pubmed/30209405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31939-9 |
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