Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D (2) receptor activation using multi‐biomarker pharmacokinetic/pharmacodynamic modelling

BACKGROUND AND PURPOSE: Because biological systems behave as networks, multi‐biomarker approaches increasingly replace single biomarker approaches in drug development. To improve the mechanistic insights into CNS drug effects, a plasma neuroendocrine fingerprint was identified using multi‐biomarker...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: van den Brink, Willem J, van den Berg, Dirk‐Jan, Bonsel, Floor E M, Hartman, Robin, Wong, Yin‐Cheong, van der Graaf, Piet H, de Lange, Elizabeth C M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135786/
https://ncbi.nlm.nih.gov/pubmed/30051461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14452
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