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Dimerization misalignment in human glutamate-oxaloacetate transaminase variants is the primary factor for PLP release
The active form of vitamin B6, pyridoxal 5’-phosphate (PLP), plays an essential role in the catalytic mechanism of various proteins, including human glutamate-oxaloacetate transaminase (hGOT1), an important enzyme in amino acid metabolism. A recent molecular and genetic study showed that the E266K,...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6135512/ https://ncbi.nlm.nih.gov/pubmed/30208107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203889 |
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