Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index

Most solid tumors have their own cancer stem cells (CSCs), which are resistant to standard chemo-therapies. Recent reports have described that Wnt pathway plays a key role in self-renewal and tumorigenesis of CSCs. Regarding the Wnt/β-catenin pathway, Dvl (mammalian Disheveled) is an attractive targ...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Hori, Kiminori, Ajioka, Kasumi, Goda, Natsuko, Shindo, Asako, Takagishi, Maki, Tenno, Takeshi, Hiroaki, Hidekazu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134994/
https://ncbi.nlm.nih.gov/pubmed/30233369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00983
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