Impairment of the transition from proliferative stage to prehypertrophic stage in chondrogenic differentiation of human induced pluripotent stem cells harboring the causative mutation of achondroplasia in fibroblast growth factor receptor 3

INTRODUCTION: Achondroplasia (ACH) is a congenital disease which causes dwarfism and many symptoms resulting from skeletal dysplasia. Because present therapeutic strategies are mainly surgical procedures as symptomatic treatments, development of a radical treatment is desired. Clarification of the A...

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Vydáno v:Regen Ther
Hlavní autoři: Horie, Naohiro, Hikita, Atsuhiko, Nishizawa, Satoru, Uto, Sakura, Takato, Tsuyoshi, Hoshi, Kazuto
Médium: Artigo
Jazyk:Inglês
Vydáno: Japanese Society for Regenerative Medicine 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134919/
https://ncbi.nlm.nih.gov/pubmed/30271835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reth.2016.11.002
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