Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis

B cells are implicated in rheumatoid arthritis (RA) based on the presence of autoantibodies and the therapeutic response to B cell depletion. IL-21 has a significant role in B cell development and function. Here we assess B cell responses to IL-21 and the mechanisms responsible for altered IL-21R ex...

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Vydáno v:Front Immunol
Hlavní autoři: Dam, Elizabeth M., Maier, Alison C., Hocking, Anne M., Carlin, Jeffrey, Ng, Bernard, Buckner, Jane H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6134023/
https://ncbi.nlm.nih.gov/pubmed/30233580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01978
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