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Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogs of 2-C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens
Targeting essential bacterial processes beyond cell wall, protein, nucleotide, and folate syntheses holds promise to reveal new antimicrobial agents and expand the potential drugs available for combination therapies. The synthesis of isoprenoid precursors, isopentenyl diphosphate (IDP) and dimethyla...
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| Yayımlandı: | J Org Chem |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6133773/ https://ncbi.nlm.nih.gov/pubmed/29870251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.8b00686 |
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