Selection of Antibodies with Tailored Properties by Application of High-Throughput Multiparameter Fluorescence-Activated Cell Sorting of Yeast-Displayed Immune Libraries

In this study, we present a multiparameter screening procedure for the identification of target-specific antibodies with prescribed properties. Based on B cell receptor gene repertoires from transgenic rats, yeast surface display libraries were generated, and high-affinity human antibodies were read...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Biotechnol
Main Authors: Schröter, Christian, Beck, Jan, Krah, Simon, Zielonka, Stefan, Doerner, Achim, Rhiel, Laura, Günther, Ralf, Toleikis, Lars, Kolmar, Harald, Hock, Björn, Becker, Stefan
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2018
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132741/
https://ncbi.nlm.nih.gov/pubmed/30076531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12033-018-0109-0
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