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Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices

Propofol is the most frequently used intravenous anesthetic for induction and maintenance of anesthesia. Propofol acts first and formost as a GABA(A)-agonist, but effects on other neuronal receptors and voltage-gated ion channels have been described. Besides its direct effect on neurotransmission, p...

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Bibliografiske detaljer
Udgivet i:Arch Toxicol
Main Authors: Berndt, Nikolaus, Rösner, Jörg, Haq, Rizwan ul, Kann, Oliver, Kovács, Richard, Holzhütter, Hermann-Georg, Spies, Claudia, Liotta, Agustin
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132669/
https://ncbi.nlm.nih.gov/pubmed/30143847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2295-8
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