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The effect of food and liquid pH on the integrity of enteric-coated beads from cysteamine bitartrate delayed-release capsules

BACKGROUND: Cysteamine bitartrate delayed-release (DR) capsule (Procysbi(®)) is approved for treatment of nephropathic cystinosis in the USA, Canada, and the EU. The capsules contain cysteamine bitartrate beads that are enteric coated with acid-resistant Eudragit L 30 D-55, preventing drug release i...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Pavloff, Nadine, Hauser, Terry A, Williams, Chris, Isbell, Sara Louis, Cadieux, Ben, Johnson, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132578/
https://ncbi.nlm.nih.gov/pubmed/30233142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S174928
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