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Methyl group reorientation under ligand binding probed by pseudocontact shifts

Liquid-state NMR spectroscopy is a powerful technique to elucidate binding properties of ligands on proteins. Ligands binding in hydrophobic pockets are often in close proximity to methyl groups and binding can lead to subtle displacements of methyl containing side chains to accommodate the ligand....

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Bibliografski detalji
Izdano u:J Biomol NMR
Glavni autori: Lescanne, Mathilde, Ahuja, Puneet, Blok, Anneloes, Timmer, Monika, Akerud, Tomas, Ubbink, Marcellus
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2018
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132577/
https://ncbi.nlm.nih.gov/pubmed/29860649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-018-0190-5
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