The Role of N-Acetylcysteine Supplementation on the Oxidative Stress Levels, Genotoxicity and Lineage Commitment Potential of Ex Vivo Murine Haematopoietic Stem/Progenitor Cells

OBJECTIVES: The ex vivo maintenance of haematopoietic stem/progenitor cells (HSPCs) is crucial to ensure a sufficient supply of functional cells for research or therapeutic applications. However, when exposed to reactive oxygen species (ROS) in a normoxic microenvironment, HSPCs exhibit genomic inst...

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Udgivet i:Sultan Qaboos Univ Med J
Main Authors: Hamid, Zariyantey A., Tan, Hui Y., Chow, Paik W., Harto, Khairul A. W., Chan, Chin Yi, Mohamed, Jamaludin
Format: Artigo
Sprog:Inglês
Udgivet: Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences 2018
Fag:
Clinical & Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132511/
https://ncbi.nlm.nih.gov/pubmed/30210840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18295/squmj.2018.18.02.002
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