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Four novel mutations in the ALPL gene in Chinese patients with odonto, childhood, and adult hypophosphatasia

Hypophosphatasia (HPP) is a rare inherited disorder characterized by defective bone and/or dental mineralization, and decreased serum alkaline phosphatase (ALP) activity. ALPL, the only gene related with HPP, encodes tissue non-specific ALP (TNSALP). Few studies were carried out in ALPL gene mutatio...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Xu, Lijun, Pang, Qianqian, Jiang, Yan, Wang, Ou, Li, Mei, Xing, Xiaoping, Xia, Weibo
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131208/
https://ncbi.nlm.nih.gov/pubmed/29724887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20171377
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