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High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP(+)

A high-pressure crystallographic study was conducted on Escherichia coli dihydrofolate reductase (ecDHFR) complexed with folate and NADP(+) in crystal forms containing both the open and closed conformations of the M20 loop under high-pressure conditions of up to 800 MPa. At pressures between 270 and...

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Veröffentlicht in:Acta Crystallogr D Struct Biol
Hauptverfasser: Nagae, Takayuki, Yamada, Hiroyuki, Watanabe, Nobuhisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130465/
https://ncbi.nlm.nih.gov/pubmed/30198899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798318009397
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