Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction

Adeno-associated viral vector–mediated (AAV-mediated) expression of allogeneic major histocompatibility complex class I (MHC class I) in recipient liver induces donor-specific tolerance in mouse skin transplant models in which a class I allele (H-2K(b) or H-2K(d)) is mismatched between donor and rec...

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Vydáno v:JCI Insight
Hlavní autoři: Paul-Heng, Moumita, Leong, Mario, Cunningham, Eithne, Bunker, Daniel L. J., Bremner, Katherine, Wang, Zane, Wang, Chuanmin, Tay, Szun Szun, McGuffog, Claire, Logan, Grant J., Alexander, Ian E., Hu, Min, Alexander, Stephen I., Sparwasser, Tim D., Bertolino, Patrick, Bowen, David G., Bishop, G. Alex, Sharland, Alexandra
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129134/
https://ncbi.nlm.nih.gov/pubmed/30089715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97500
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