Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction

Adeno-associated viral vector–mediated (AAV-mediated) expression of allogeneic major histocompatibility complex class I (MHC class I) in recipient liver induces donor-specific tolerance in mouse skin transplant models in which a class I allele (H-2K(b) or H-2K(d)) is mismatched between donor and rec...

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Udgivet i:JCI Insight
Main Authors: Paul-Heng, Moumita, Leong, Mario, Cunningham, Eithne, Bunker, Daniel L. J., Bremner, Katherine, Wang, Zane, Wang, Chuanmin, Tay, Szun Szun, McGuffog, Claire, Logan, Grant J., Alexander, Ian E., Hu, Min, Alexander, Stephen I., Sparwasser, Tim D., Bertolino, Patrick, Bowen, David G., Bishop, G. Alex, Sharland, Alexandra
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129134/
https://ncbi.nlm.nih.gov/pubmed/30089715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97500
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