Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors

The ability to restrict low molecular weight compounds to the gastrointestinal (GI) tract may enable an enhanced therapeutic index for molecular targets known to be associated with systemic toxicity. Using a triazolopyrazine CSF1R inhibitor scaffold, a broad range of prodrugs were synthesized and ev...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: George, Dawn M., Huntley, Raymond J., Cusack, Kevin, Duignan, David B., Hoemann, Michael, Loud, Jacqueline, Mario, Regina, Melim, Terry, Mullen, Kelly, Somal, Gagandeep, Wang, Lu, Edmunds, Jeremy J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128612/
https://ncbi.nlm.nih.gov/pubmed/30192846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203567
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia