Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane

Cholera toxin (CT) causes severe diarrhea by increasing intracellular cAMP leading to a PKA-dependent increase in Cl(−) secretion through CFTR and decreased Na(+) absorption through inhibition of Na(+)/H(+) exchanger 3 (NHE3; also known as SLC9A3). The mechanism(s) by which CT inhibits NHE3 is parti...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Singh, Varsha, Yang, Jianbo, Yin, Jianyi, Cole, Robert, Tse, Ming, Berman, Diego E., Small, Scott A., Petsko, Gregory, Donowitz, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127729/
https://ncbi.nlm.nih.gov/pubmed/30030371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.218610
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