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GSK-3β Inhibitor Alsterpaullone Attenuates MPP(+)-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells
Mitochondrial dysfunction plays significant roles in the pathogenesis of Parkinson’s Disease (PD). The inactivation of c-Myc, a down-stream gene of Wnt/β-catenin signaling, may contribute to the mitochondria dysfunction. Inhibition of glycogen synthase kinase 3β (GSK-3β) with Alsterpaullone (Als) ca...
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| Publicado no: | Front Cell Neurosci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6127625/ https://ncbi.nlm.nih.gov/pubmed/30233322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00283 |
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