Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

Squamous cell carcinomas (SCCs) are aggressive malignancies. Previous report demonstrated that master transcription factors (TFs) TP63 and SOX2 exhibited overlapping genomic occupancy in SCCs. However, functional consequence of their frequent co-localization at super-enhancers remains incompletely u...

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Publicado en:Nat Commun
Autores principales: Jiang, Yuan, Jiang, Yan-Yi, Xie, Jian-Jun, Mayakonda, Anand, Hazawa, Masaharu, Chen, Li, Xiao, Jin-Fen, Li, Chun-Quan, Huang, Mo-Li, Ding, Ling-Wen, Sun, Qiao-Yang, Xu, Liang, Kanojia, Deepika, Jeitany, Maya, Deng, Jian-Wen, Liao, Lian-Di, Soukiasian, Harmik J., Berman, Benjamin P., Hao, Jia-Jie, Xu, Li-Yan, Li, En-Min, Wang, Ming-Rong, Bi, Xin-Gang, Lin, De-Chen, Koeffler, H. Phillip
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127298/
https://ncbi.nlm.nih.gov/pubmed/30190462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06081-9
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