E proteins sharpen neurogenesis by modulating proneural bHLH transcription factors’ activity in an E-box-dependent manner

Class II HLH proteins heterodimerize with class I HLH/E proteins to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting the neurogenic strength of the distinct proneural proteins. We find that inhibiting BMP signaling or its target ID2 in the chick embryo spinal c...

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Pubblicato in:eLife
Autori principali: Le Dréau, Gwenvael, Escalona, René, Fueyo, Raquel, Herrera, Antonio, Martínez, Juan D, Usieto, Susana, Menendez, Anghara, Pons, Sebastian, Martinez-Balbas, Marian A, Marti, Elisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126921/
https://ncbi.nlm.nih.gov/pubmed/30095408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37267
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