Biophysical and functional characterization of Norrin signaling through Frizzled4

Wnt signaling is initiated by Wnt ligand binding to the extracellular ligand binding domain, called the cysteine-rich domain (CRD), of a Frizzled (Fzd) receptor. Norrin, an atypical Fzd ligand, specifically interacts with Fzd4 to activate β-catenin–dependent canonical Wnt signaling. Much of the mole...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Bang, Injin, Kim, Hee Ryung, Beaven, Andrew H., Kim, Jinuk, Ko, Seung-Bum, Lee, Gyu Rie, Kan, Wei, Lee, Hasup, Im, Wonpil, Seok, Chaok, Chung, Ka Young, Choi, Hee-Jung
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126767/
https://ncbi.nlm.nih.gov/pubmed/30104375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805901115
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