Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells

BACKGROUND: IL-6 classic signaling is linked to anti-inflammatory functions while the trans-signaling is associated with pro-inflammatory responses. Classic signaling is induced via membrane-bound IL-6 receptor (IL-6R) whereas trans-signaling requires prior binding of IL-6 to the soluble IL-6R. In b...

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Udgivet i:Cell Commun Signal
Main Authors: Zegeye, Mulugeta M., Lindkvist, Madelene, Fälker, Knut, Kumawat, Ashok K., Paramel, Geena, Grenegård, Magnus, Sirsjö, Allan, Ljungberg, Liza U.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125866/
https://ncbi.nlm.nih.gov/pubmed/30185178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-018-0268-4
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