Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis

Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of fluconazole penetration into the central nervous system (CNS) is not known. A fluconazole PK study was conducted in 43 patients receiving oral fluconazole (usually 800 mg every 24 h [q24h]) in combination with...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Stott, Katharine E., Beardsley, Justin, Kolamunnage-Dona, Ruwanthi, Castelazo, Anahi Santoyo, Kibengo, Freddie Mukasa, Mai, Nguyen Thi Hoang, Tùng, Nguyễn Lê Nhu’, Cuc, Ngo Thi Kim, Day, Jeremy, Hope, William
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125572/
https://ncbi.nlm.nih.gov/pubmed/29914943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00885-18
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