Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis

Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of fluconazole penetration into the central nervous system (CNS) is not known. A fluconazole PK study was conducted in 43 patients receiving oral fluconazole (usually 800 mg every 24 h [q24h]) in combination with...

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發表在:Antimicrob Agents Chemother
Main Authors: Stott, Katharine E., Beardsley, Justin, Kolamunnage-Dona, Ruwanthi, Castelazo, Anahi Santoyo, Kibengo, Freddie Mukasa, Mai, Nguyen Thi Hoang, Tùng, Nguyễn Lê Nhu’, Cuc, Ngo Thi Kim, Day, Jeremy, Hope, William
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2018
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125572/
https://ncbi.nlm.nih.gov/pubmed/29914943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00885-18
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