Is It Time for Systematic Voriconazole Pharmacogenomic Investigation for Central Nervous System Aspergillosis?

Voriconazole is the standard treatment for invasive aspergillosis but requires therapeutic drug monitoring to optimize therapy. We report two cases of central nervous system aspergillosis treated with voriconazole. Because of low trough plasma concentrations, we identified gain-of-function mutations...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Danion, François, Jullien, Vincent, Rouzaud, Claire, Abdel Fattah, Manal, Lapusan, Simona, Guéry, Romain, Bigé, Naïke, Morgand, Marjolaine, Pallet, Nicolas, Lanternier, Fanny, Lortholary, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125540/
https://ncbi.nlm.nih.gov/pubmed/29967027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00705-18
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