Mapping the Interface of a GPCR Dimer: A Structural Model of the A(2A) Adenosine and D(2) Dopamine Receptor Heteromer

The A(2A) adenosine (A(2A)R) and D(2) dopamine (D(2)R) receptors form oligomers in the cell membrane and allosteric interactions across the A(2A)R–D(2)R heteromer represent a target for development of drugs against central nervous system disorders. However, understanding of the molecular determinant...

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Publicat a:Front Pharmacol
Autors principals: Borroto-Escuela, Dasiel O., Rodriguez, David, Romero-Fernandez, Wilber, Kapla, Jon, Jaiteh, Mariama, Ranganathan, Anirudh, Lazarova, Tzvetana, Fuxe, Kjell, Carlsson, Jens
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125358/
https://ncbi.nlm.nih.gov/pubmed/30214407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00829
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