Inclusion of the murine IgGκ signal peptide increases the cellular immunogenicity of a simian adenoviral vectored Plasmodium vivax multistage vaccine

INTRODUCTION: Cellular and humoral immune responses are both involved in protection against Plasmodium infections. The only malaria vaccine available, RTS,S, primarily induces short-lived antibodies and targets only a pre-erythrocytic stage antigen. Inclusion of erythrocytic stage targets and enhanc...

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Publicat a:Vaccine
Autors principals: Fonseca, Jairo A., McCaffery, Jessica N., Caceres, Juan, Kashentseva, Elena, Singh, Balwan, Dmitriev, Igor P., Curiel, David T., Moreno, Alberto
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124663/
https://ncbi.nlm.nih.gov/pubmed/29657070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2018.03.091
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