Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor‐1α Hydroxylase Inhibitors

The transcriptional profile induced by hypoxia plays important roles in the chondrogenic differentiation of marrow stromal/stem cells (MSC) and is mediated by the hypoxia inducible factor (HIF) complex. However, various compounds can also stabilize HIF's oxygen‐responsive element, HIF‐1α, at no...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Taheem, Dheraj K., Foyt, Daniel A., Loaiza, Sandra, Ferreira, Silvia A., Ilic, Dusko, Auner, Holger W., Grigoriadis, Agamemnon E., Jell, Gavin, Gentleman, Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Regenerative Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124654/
https://ncbi.nlm.nih.gov/pubmed/29726060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2844
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