Paternal cholestasis exacerbates obesity-associated hypertension in male offspring but is prevented by paternal ursodeoxycholic acid treatment

BACKGROUND: Obesity is a heterogeneous phenotype and risk associations to non-communicable diseases such as cardiovascular disease and type 2 diabetes are influenced by several factors. The paternal metabolic status at the time of conception influences offspring susceptibility to developing obesity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Obes (Lond)
Prif Awduron: Pataia, Vanessa, Papacleovoulou, Georgia, Nikolova, Vanya, Samuelsson, Anne-Maj, Chambers, Stephanie, Jansen, Eugene, Taylor, Paul D, Poston, Lucilla, Williamson, Catherine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124644/
https://ncbi.nlm.nih.gov/pubmed/29795465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-018-0095-0
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