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Inhibiting neutral amino acid transport for the treatment of phenylketonuria
The neuropathological effects of phenylketonuria (PKU) stem from the inability of the body to metabolize excess phenylalanine (Phe), resulting in accumulation of Phe in the blood and brain. Since the kidney normally reabsorbs circulating amino acids with high efficiency, we hypothesized that prevent...
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| Publicado no: | JCI Insight |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6124451/ https://ncbi.nlm.nih.gov/pubmed/30046012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121762 |
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