Monocyte NOTCH2 expression predicts IFN-β immunogenicity in multiple sclerosis patients

Multiple sclerosis (MS) is an autoimmune disease characterized by CNS inflammation leading to demyelination and axonal damage. IFN-β is an established treatment for MS; however, up to 30% of IFN-β–treated MS patients develop neutralizing antidrug antibodies (nADA), leading to reduced drug bioactivit...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Adriani, Marsilio, Nytrova, Petra, Mbogning, Cyprien, Hässler, Signe, Medek, Karel, Jensen, Poul Erik H., Creeke, Paul, Warnke, Clemens, Ingenhoven, Kathleen, Hemmer, Bernhard, Sievers, Claudia, Lindberg Gasser, Raija L.P., Fissolo, Nicolas, Deisenhammer, Florian, Bocskei, Zsolt, Mikol, Vincent, Fogdell-Hahn, Anna, Kubala Havrdova, Eva, Broët, Philippe, Dönnes, Pierre, Mauri, Claudia, Jury, Elizabeth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124413/
https://ncbi.nlm.nih.gov/pubmed/29875313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99274
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