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A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics
G-protein-coupled receptors (GPCRs) represent one of the most important classes of drug targets. The discovery of new GCPR therapeutics would greatly benefit from the development of a generalizable high-throughput assay to directly monitor their activation or de-activation. Here we screened a variet...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123785/ https://ncbi.nlm.nih.gov/pubmed/30271985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0072-0 |
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