The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

Computational modeling indicates that cardiac conduction may involve ephaptic coupling – intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We hypothesized that β1(SCN1B) –mediated adhesion scaffolds trans-activating Na(V)1.5 (S...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Veeraraghavan, Rengasayee, Hoeker, Gregory S, Alvarez-Laviada, Anita, Hoagland, Daniel, Wan, Xiaoping, King, D Ryan, Sanchez-Alonso, Jose, Chen, Chunling, Jourdan, Jane, Isom, Lori L, Deschenes, Isabelle, Smyth, James W, Gorelik, Julia, Poelzing, Steven, Gourdie, Robert G
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122953/
https://ncbi.nlm.nih.gov/pubmed/30106376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37610
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