Augmented Insulin and Leptin Resistance of High Fat Diet-Fed APPswe/PS1dE9 Transgenic Mice Exacerbate Obesity and Glycemic Dysregulation

Alzheimer’s disease (AD), a progressive neurodegenerative disease is highly associated with metabolic syndromes. We previously demonstrated that glycemic dysregulation and obesity are augmented in high fat diet (HFD)-treated APPswe/PS1dE9 (APP/PS1) transgenic mice. In the current study, the underlyi...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Lee, Yi-Heng, Hsu, Hao-Chieh, Kao, Pei-Chen, Shiao, Young-Ji, Yeh, Skye Hsin-Hsien, Shie, Feng-Shiun, Hsu, Shu-Meng, Yeh, Chih-Wen, Liu, Hui-Kang, Yang, Shi-Bing, Tsay, Huey-Jen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121904/
https://ncbi.nlm.nih.gov/pubmed/30096853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19082333
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