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Efflux inhibition by IWR-1-endo confers sensitivity to doxorubicin effects in osteosarcoma cells

Osteosarcoma is the most common bone tumor that affects children and young adults. Despite advances in the use of combination chemotherapy regimens, response to neoadjuvant chemotherapy in osteosarcoma remains a key determinant of patient outcome. Recently, highly potent small molecule inhibitors of...

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Publicado en:Biochem Pharmacol
Autores principales: Gustafson, Carl T., Mamo, Tewodros, Maran, Avudaiappan, Yaszemski, Michael J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121219/
https://ncbi.nlm.nih.gov/pubmed/29412166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.01.037
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