Cell-Free DNA Profiling to Discover Mechanisms of Exceptional Response to Cabozantinib Plus Panitumumab in a Patient With Treatment Refractory Metastatic Colorectal Cancer

MET amplification is rare in treatment-naïve metastatic colorectal cancer (CRC) tumors, but can emerge as a mechanism of resistance to anti-EGFR therapies. Preclinical and clinical data suggest that patients with MET amplified tumors benefit from MET-targeted therapy. Cabozantinib is an inhibitor of...

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Detaylı Bibliyografya
Yayımlandı:Front Oncol
Asıl Yazarlar: Jia, Jingquan, Morse, Michael A., Nagy, Rebecca J., Lanman, Richard B., Strickler, John H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018
Konular:
Oncology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121109/
https://ncbi.nlm.nih.gov/pubmed/30211110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00305
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