ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

Maintenance of cellular proteostasis relies on efficient clearance of defective gene products. For misfolded secretory proteins, this involves dislocation from the endoplasmic reticulum (ER) into the cytosol followed by proteasomal degradation. However, polypeptide aggregation prevents cytosolic dis...

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Bibliographic Details
Published in:EMBO J
Main Authors: Fregno, Ilaria, Fasana, Elisa, Bergmann, Timothy J, Raimondi, Andrea, Loi, Marisa, Soldà, Tatiana, Galli, Carmela, D'Antuono, Rocco, Morone, Diego, Danieli, Alberto, Paganetti, Paolo, van Anken, Eelco, Molinari, Maurizio
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120659/
https://ncbi.nlm.nih.gov/pubmed/30076131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899259
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